Where is the Origin of Chronic Pain?
Chronic
pain has been an ongoing battle for many individuals, which seems to have no
permanent cure. Chronic pain is classified as neuropathic; because there is impairment
to the nerve cells. Examples of chronic pain include Rheumatoid Arthritis, Phantom
Limb Syndrome, and side effects resulting from a stroke. There has been a new
study that has been done by researchers at The University of Texas at Dallas,
UT MD Anderson
Cancer Center, UT Health Science Center at Houston and Baylor College of
Medicine that have found new evidence as to where chronic pain originates from,
as well as multiple target points for treating chronic pain. The research study
looks at concentrated nerve cells that are found near the base of the spinal
cord. This grouping of concentrated nerve cells, called the dorsal root
ganglia, gave the researchers a once in a life time chance to study them due to
them being removed by surgery from cancer patients. The researches classified
different RNA terminologies in the dorsal root ganglia cells. These different RNA
terminologies come from differing patients by a couple of varying factors; the
amount of pain that they are in as well as their sex, whether they are male or
female. The explanation for whether or not the patient was male, or female is because
it was found that men and women have different amounts of pain depending on
their sex. Using the specific sequencing with the RNA, the dorsal root ganglia
cells aided an idea of biochemical pathways which may enable researchers to formulate
pain-relieving medications. After careful analysis of the results of this study,
it was found that studies done to rats for chronic pain have been successful in
generalization, but there is a missing component, which is accuracy.
In
class, we discussed the dorsal root ganglia cells when we were talking about
hearing and vision; how the dorsal is located in the back and the ganglia cells
are clusters of cells. The dorsal aspect was specifically brought up when
talking about hearing and seeing. Dorsal is the “where” processing system. For
example, when it comes to vision, the dorsal stream is involved in locating
objects. Chronic pain is a crucial part in understanding how the brain and body
work in conjunction with one another because there are pain pathways that send
signals from the brain down to the body which in turn causes the body to feel
pain. For example, if one were to burn their finger, there is a signal that
gets sent to the spinal cord, which then sends a signal back to respond to that
painful stimulus.
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