REWINDING THE CLOCK - https://hms.harvard.edu/news/rewinding-clock

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The “Fountain of Youth” could finally be making a presence in modern day, or at least in the form of a pill someone can easily take. David Sinclair, the senior investigator at Harvard Genetics Facility, is reversing vascular aging processes. Sinclair believes age is the reason behind vascular diseases and complications in realms of cardiac, neural, muscle loss, and many others. So Sinclair has focused on endothelial cells that line blood vessels. These cells play a key role creating new healthy capillaries and increasing blood flow to organs, tissues, and muscles. John Medina, the author of Brain Rules, pointed out the importance behind healthy, regular blood flow in order to deliver oxygen and necessary nutrients in these areas. Higher blood flow resulted in better functioning, especially in the brain like battling stressors and retaining memory.
Endothelial cells decline with age due to losing a key protein Sirtuin1 (SIRT1), which delays aging processes. SIRT1 begins to decline with age as well because another key protein, NAD+, that boosts SIRT1 dies away. So Sinclair focused on boosting NAD+ to increase SIRT1 activity. Lab dish experiments from humans and mice were given NMN, a chemical compound precursor of NAD+. Results showed enhanced growth capacity of capillaries and reduced cell death.
NMN boosts NAD+ in a way the human body would experience during exercise, like increased blood flow. Medina also emphasized the importance of exercising, explaining how 20-30 minutes of walking a few days out of a week could help prevent vascular diseases and many other neurological illness by at least 60%. Sinclair experimented with NMN given to 20-month-old mice (about 70 human years) and a combination of NMN and NaHS (another enhancer of SIRT1) in 32-month-old mice (about 90 human years). Compared to untreated mice, the results indicated a significant increase in just NMN treated mice , increasing abilities to exercise, number of capillaries generated, and blood flow. Mice given the combination of NMN and NaHS showed an even greater result doubling the duration and ability to exercise compared to untreated mice. Currently, Sinclair takes NMN daily himself, and plans to continue replicating his findings in human trials.
This article explains how Sinclair is fighting against aging processes and eliminating numerous types of vascular diseases by giving a NMN booster shot to the body’s natural components (SIRT1 and NAD+). In relation to the article, in class we understood the importance of a healthy blood flow to deliver nutrients and oxygen needed in our tissues, organs, and brain. This prevents heart attacks, strokes, plaque build up, and many others affecting a span of areas in our body.

 Link to article: https://hms.harvard.edu/news/rewinding-clock

Comments

  1. Robert ZeiglerApril 19, 2019 at 2:54 PM

    This article only explains a gist of the NMN (NAD+ booster), but i heard about David Sinclair from a 3 hour (WORTH LISTENING TO) podcast on the Joe Rogan Experience. During the podcast David Sinclair gives a better understanding of his work, as this article only surrounds the NAD+ booster shot and what it effects. Sinclair explains a lot more about how these natural components also protect and repair our genetic code and ways to prevent damaging. Lastly, naming other ways he prevents aging processes! Check out the podcast!

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    Replies
    1. Robert ZeiglerApril 19, 2019 at 2:56 PM

      http://blog.insidetracker.com/joe-rogan-experience-podcast-david-sinclair

      ^^ Link to podcast

      Delete
  2. Keeley ButtersApril 21, 2019 at 9:56 PM

    I found this really interesting and so I did a little research into endothelial cells. A study was conducted that used bone marrow endothelial cells to aid in reviving the hematopoietic system in aging mice. The hematopoietic system consists of the organs and tissues that are involved in the production of blood. The researchers found that when they introduced the bone marrow endothelial cells into the aging mice, it rejuvenated the hematopoietic stem cells and increased B and T cell numbers, but the results were not found in younger mice. This could suggest that the endothelial cells also aid in immune function in aging people. This article helps to serve as evidence for David Sinclair's hypothesis. I have not learned about endothelial cells and their relation to aging in my biology classes, rather how telomeres contribute to aging. I think that endothelial cells could be the way to go in the research of aging.
    https://www.jci.org/articles/view/97707

    ReplyDelete

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