Depression to Diabetes?
https://pdf.sciencedirectassets.com/271200/1-s2.0-S0006322300X04015/1-s2.0-S0006322303005699/main.pdf?x-amz-security-token=AgoJb3JpZ2luX2VjEL%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQDhXJSbThAaRr4Rg%2FqR5uGaHY7j1SrvlqLzRCSFybzuNgIgcCgMvtVQ8TMQ65v4PHH626qnYEEVFDiwjcMrt0obVcUq4wMImP%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARACGgwwNTkwMDM1NDY4NjUiDNg7pgdFewYvadnOlCq3A08xSR8aGlbxJ%2BaKbDAbwTO1YI3A7lOAmspsuGns4sPIFuR0XX0W7elCENWeRcK6WboF4QTNPQVZYVu8%2FE9UyoanITybu3GD4HUa3Dk2EOiFP%2FE5jzmBUNvDYCoMaNLnM9EIU2XDbjkmCORes3zm0EMzAt53%2BExv1dQWOfCS8pI6Ybt7uABiUvwnIl2AnWslrAHznWvm8y3mRbfCctStEaDW3oZQcytMPqFiKA8jEatgg02%2Fd%2BqLQXmrH7dg6FcGmtBbwCqXkZ0DzsWu49MHhLbtsBdgO6xFzPHWE7tGl1XkxMjlT%2B2%2FI0PhKOyyELpsNu8l8RbsrGJ9LovTAVRdhHthG1RLvZkpJ8bBcY8ClFSqbwmivRRT4j808w4zr2%2BhZy90VOx0xcVOm85f8BGEu0A2Rx5q%2F8SkNsupvuTZ1X0MUxm8lErLOIMOKR0S%2BDgLtDRiW8o1XZoUuTjLGEFemTjuKuFYq3bdP%2BjTuJr2wxuf%2FaQblsAVpDsFrb4irmqiqpULIAbN8iIYyo2LSRpChYJJv7zaoRMJv0FagbHeT%2FRdOFyycl%2BzPAqVRTYs5pdi%2Fz5l6hXhUfIwmNzz5QU6tAHMMSgIF4auHlCRCgx5zlq2J%2B7YDjgxfQLK73LQ1%2Foe8GAAcPZh1CURSM0dhFqx%2FMbUbRXWwNhDFjNxi4ai8fyoVGACxOsIFUxbGMWuC5jn8OqWQhI%2Bp0UiIX8Nk9WSPsLRBxjgEwxMiDUFTsUUwa5BfLVV%2FsFZ0wICvkH8iZSnd0wiK7yNrBLbmmEzKtgKA2BfqHpAtIvsRhOkDb3JFU7Q1WK4pN8aQV7TIZUwrlMQ8CBT9EA%3D&AWSAccessKeyId=ASIAQ3PHCVTYWQHGL5GZ&Expires=1555887278&Signature=ywoViUEWA0p7CIVWiBlUive%2Bil8%3D&hash=df5f025f2e3d4c04bc09c81a98edebc39755b68473abf0812fabab69ff56dc83&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0006322303005699&tid=spdf-3f0739a8-2758-40db-b843-c086301d101f&sid=f28a69b42522834f961ad3f76d0689c98fecgxrqa&type=client
This article demonstrates that depression constitutes a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. The article discussed how people with diabetes were diagnosed with depression. In this study specifically patients were evaluated using a self-report questionnaire. It also assessed how prevalent depression is in diabetic patients this too was measured using self-report questionnaires. Then, how sociocultural and medical risk factors play a role such as socioeconomic status, race, education, gender, etc. Next, the impact co-morbidity has on patients, how depression alters the biology of the body, and finally how different treatments effect them.
Diabetes results when the pancreas is unable to produce enough insulin (type 1 diabetes ) or the body's tissues are relatively unresponsive to insulin (type 2 diabetes) (Garrett & Hough, 2018). We covered this topic in chapter 6. In major (or unipolar) depressive disorder (MDD), a person often feels sad to the point of hopelessness for weeks at a time; loses the ability to enjoy life, relationships, and sex;and experiences loss of energy and appetite, slowness of thought, and sleep disturbance. In some cases, the person is also agitated or restless (Garrett & Hough, 2018). Psychological stress is a perceived challenge to well being, is accompanied by release of counter-regulatory hormones (i.e., catecholamines, glucocorticoids, growth hormone [GH], and glucagon), which counteract insulin by raising blood levels of glucose (Sapolsky et al 2000). The metabolic actions of these counter-regulatory hormones are in a delicate interplay with those of insulin and other insulin-like factors. As we read in Brain Rules the more severe stress is perceived to be, the more a person is likely to feel a loss of control or learned helplessness (Medina, 2014). This stress leads to patients decreased ability to adhere to a diabetic diet and increased lapses in filling of oral hypoglycemic medications, functional impairment,exhibit poorer glycemic control and greater prevalence of multiple diabetes complications. These impairments suggested that comorbid patients need special treatment which led to the research still being conducted today.
This article demonstrates that depression constitutes a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. The article discussed how people with diabetes were diagnosed with depression. In this study specifically patients were evaluated using a self-report questionnaire. It also assessed how prevalent depression is in diabetic patients this too was measured using self-report questionnaires. Then, how sociocultural and medical risk factors play a role such as socioeconomic status, race, education, gender, etc. Next, the impact co-morbidity has on patients, how depression alters the biology of the body, and finally how different treatments effect them.
Diabetes results when the pancreas is unable to produce enough insulin (type 1 diabetes ) or the body's tissues are relatively unresponsive to insulin (type 2 diabetes) (Garrett & Hough, 2018). We covered this topic in chapter 6. In major (or unipolar) depressive disorder (MDD), a person often feels sad to the point of hopelessness for weeks at a time; loses the ability to enjoy life, relationships, and sex;and experiences loss of energy and appetite, slowness of thought, and sleep disturbance. In some cases, the person is also agitated or restless (Garrett & Hough, 2018). Psychological stress is a perceived challenge to well being, is accompanied by release of counter-regulatory hormones (i.e., catecholamines, glucocorticoids, growth hormone [GH], and glucagon), which counteract insulin by raising blood levels of glucose (Sapolsky et al 2000). The metabolic actions of these counter-regulatory hormones are in a delicate interplay with those of insulin and other insulin-like factors. As we read in Brain Rules the more severe stress is perceived to be, the more a person is likely to feel a loss of control or learned helplessness (Medina, 2014). This stress leads to patients decreased ability to adhere to a diabetic diet and increased lapses in filling of oral hypoglycemic medications, functional impairment,exhibit poorer glycemic control and greater prevalence of multiple diabetes complications. These impairments suggested that comorbid patients need special treatment which led to the research still being conducted today.
Taia,
ReplyDeleteThis is an interesting correlation between depression and diabetes that you've presented. Given the relationships we've discussed in class between the gut microbiome and depression, dietary intake and diabetes, and dietary intake and the gut microbiome, it would make sense that depression and diabetes would have some type of connection in a significant population. It would be interesting to examine if treatment of depression through the gut microbiome had any effect on diabetes and vice versa.
Diabetes Type 1 also presents connections to depression. However, the set of causes are somewhat different than the ones you have provided: emotional and psychologically. From the constant monitoring of carbs, dietary restrictions, blood sugar, and having to administer insulin every single day, Diabetes Type 1 (and 2) are extremely emotionally-taxing. Because of the symptoms and the constant worrying, someone with this condition will have a lower quality of life. Not to mention the addition of more medical care leading to higher medical bills. This could lead to not just depression, but also an anxiety disorder.
ReplyDeletehttps://beyondtype1.org/depression-and-its-relationship-to-type-1/
Hey Taia,
ReplyDeleteI found another article which touches on the relationship between diabetes and mental illness: here, researchers blocked the expression of insulin and insulin-like growth factor receptors in the amygdala and hippocampus of mice and found a similar loss in memory and learning to what one might expect from Alzheimer's disease. The researchers singled out glutamate receptor 1, which is involve in both cognitive and metabolic processes, as being the primary cause of the mice's cognitive decline, as it was responsible for the formation of synaptic connections throughout the brain.
https://neurosciencenews.com/insulin-signaling-failure-alzheimers-10894/