Gut Bacteria and it's Relationship to Dementia Risk
https://www.usnews.com/news/health-news/articles/2019-01-31/could-gut-bacteria-be-linked-to-dementia-risk
Recent studies have shown that gut microbiome go beyond aiding digestion. They have shown to affect a large range of our body functions such as immune defense and relaying messages amongst our brain cells.
Researcher are now studying the relationship between gut microbiome and dementia risk. In Japan researchers found that "compared with dementia free older adults, those with the disease have a very different gut microbiome" (Norton, 2019). Researchers found that those with dementia had higher concentrations of ammonia, indole and phenol; but lower levels of bacteroides (Norton, 2019). Bacteroides are a group of bacteria that are beneficial to the gut due to their ability to "crowd out" infection-causing bacterias.
While studies did conclude that there was a difference in the gut microbiome it is hard to say whether this is completely conclusive. Due to our diets role in our gut make-up, and people with dementia often have changes in appetite or are malnourished, it is difficult to say whether the association is causal. It is also difficult to determine whether the gut microbiome difference or dementia came first. Researchers are continuing to study the relationships in hopes to find a strong casual relationship between the gut and dementia risk.
After learning about gut microbiome and it's effects I found it very interesting that there is a possible link between gut differentiation and a disease such as dementia. This research may eventually lead to a "diet" in hopes to slow down the progression of dementia or even prevent it. While this is still pretty new I think that it is a great start. This is a disease that affects millions and it would be a historical moment if something such as gut microbiome is a way of prevention or even treatment.
Source:
Norton, Amy. “Could Gut Bacteria Be Linked to Dementia Risk?” U.S. News & World Report, U.S. News & World Report, 31 Jan. 2019, www.usnews.com/news/health-news/articles/2019-01-31/could-gut-bacteria-be-linked-to-dementia-risk.
Recent studies have shown that gut microbiome go beyond aiding digestion. They have shown to affect a large range of our body functions such as immune defense and relaying messages amongst our brain cells.
Researcher are now studying the relationship between gut microbiome and dementia risk. In Japan researchers found that "compared with dementia free older adults, those with the disease have a very different gut microbiome" (Norton, 2019). Researchers found that those with dementia had higher concentrations of ammonia, indole and phenol; but lower levels of bacteroides (Norton, 2019). Bacteroides are a group of bacteria that are beneficial to the gut due to their ability to "crowd out" infection-causing bacterias.
While studies did conclude that there was a difference in the gut microbiome it is hard to say whether this is completely conclusive. Due to our diets role in our gut make-up, and people with dementia often have changes in appetite or are malnourished, it is difficult to say whether the association is causal. It is also difficult to determine whether the gut microbiome difference or dementia came first. Researchers are continuing to study the relationships in hopes to find a strong casual relationship between the gut and dementia risk.
After learning about gut microbiome and it's effects I found it very interesting that there is a possible link between gut differentiation and a disease such as dementia. This research may eventually lead to a "diet" in hopes to slow down the progression of dementia or even prevent it. While this is still pretty new I think that it is a great start. This is a disease that affects millions and it would be a historical moment if something such as gut microbiome is a way of prevention or even treatment.
Source:
Norton, Amy. “Could Gut Bacteria Be Linked to Dementia Risk?” U.S. News & World Report, U.S. News & World Report, 31 Jan. 2019, www.usnews.com/news/health-news/articles/2019-01-31/could-gut-bacteria-be-linked-to-dementia-risk.
This is very interesting. The recent data coming out about gut microbiomes and their association with mental illness and overall mental health is something that is fascinating to me. I am wondering however, if the microbiome is causing dementia, or the fact that dementia patients often forget how to do things like feed themselves. These patients are often fed certain soft malleable foods by others, but in more advanced cases, tube feeding may be necessary. This alteration in diet can definitely have an impact on gut bacteria I would imagine. It also makes me wonder if that perhaps there could be some form of tube feeding that is focused on reviving gut flora rather than focusing on simple nutrition alone.
ReplyDeleteWe discussed this in class the other day specifically about gut microbiome. There is a difference between good and bad bacteria so in this case bacteroides would be beneficial to have. I find it interesting how there may be a correlation between low levels of bacteroides and dementia.There is a link between gut health and the brain so there may be an influence on the brain that increases the likelihood of dementia. This area is the hippocampus which affects memory. Although, you include that there is more research to be done. I can see how there could more than just a correlation between dementia and guy microbiomes. Nice article!
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ReplyDeleteI know in class we talked about the microbiome and that relates to your article. I did some research on this and found that individuals with the disease had a very different gut "microbiome." Researchers said that it's possible that dementia was the cause of gut differences. One factor is diet, which is critical in the makeup of gut bacteria. Diet relates to dementia because people with dementia are often malnourished.
ReplyDeleteI currently work in a retirement home and some of my favorite residence that I send most of my time with are two lady's who have dementia. I work in one of the places they can eat and everyday interacting with them I have noticed their diets. Both of the lady's everyday eat the same thing, one has a chicken quesadilla and the other a hot dog. I never thought that that could possible play a role in their dementia. Since reading about how the gut bacteria and gut microbiome is different in people who dementia I wonder if it also plays a role in the food they eat. The two lady's eat the same thing for lunch everyday and probably every other meal they eat. Leading them to not have a very diverse gut microbiome, and we learned in class the other day the gut needs many different types of bacteria to be healthy.
ReplyDeleteMy topic of study related to gut microbiota and mental health as well! It's very interesting to me that this is such a new and quickly advancing topic of study. We learned in class about toxins in our diet and how pesticides can destroy gut bacteria that promote GABA production. GABA, Gamma-Amino Butyric acid, is an amino acid in the central nervous system which acts as an inhibitory neurotransmitter, such as serotonin. With a lack of serotonin, the body and brain would have a hard time inhibiting anxiety. We have also learned in class that long-term duration of stressors can damage the brain, or cause mental disorders such as anxiety or depression. According to the Physician's Committee for Responsible Medicine, a recommended diet for healthy gut microbiota includes avoiding animal products, limiting fats--especially saturated fats, eating foods high in fiber, and prebiotic and probiotic foods.
ReplyDeletehttps://www.pcrm.org/health-topics/gut-bacteria
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